In some studies, boronates are used as prodrugs, releasing the active antitumor drug in situ, which occurs following its reaction with hydrogen peroxide (H2O2). Boronate-based fluorophores and positron-emission tomography (PET) active compounds have been in cancer cells and cancer xenografts in the …
Category: Patent
Hdl mimicking targeted drug delivery system for the treatment of solid tumors
The present disclosure is directed to an SR-B1-targeting nanomicelle and compositions, methods of synthesis and methods of use thereof. The nanomicelle may be an HDL-mimetic drug delivery system and may be cross-linked with DSS. The composition may contain a therapeutic agent with the ability to …
Predicting efficiency of provided electricity during an outage
claim 1 , comprising: determining that at least one device of the group of devices is a medical device associated with an occupant of the location; determining an amount of energy required to power the medical device based on the predicted duration and the predicted severity of the event; and …
Compounds and methods for treatment of diamond blackfan anemia
8 B ) Dose-dependent effect of SMER28 (in M) on erythroid differentiation, shown as the absolute number of erythroid cells in each drug-treated condition normalized to vehicle (DMSO) control. Erythroid cells were analyzed on day 9 of differentiation using markers CD71 and GlyA. Dose curve was …
Polymeric implants with high drug loading and long-acting drug release and …
claim 1 , wherein the effective drug delivery time period is in the range of about six months to about to about 1 year. 16 . The drug delivery system of claim 1 , wherein the subject is afflicted with, susceptible to, or considered high risk for a communicable disease. 17 . The drug delivery system of
Compositions and methods for plasmapheresis
… suffer from one or more disorders associated with chronic aging. These can include Alzheimer's disease, infections, Type II Diabetes, atherosclerotic cardio vascular disease, obesity, osteoporosis, and sarcopenia. The cumulative effect is an enormous financial burden to any medical system. SUMMARY …
Antibodies to amyloid beta
However, overproduction or changes in A? levels are believed to be key events in the pathogenesis of sporadic and early onset AD. For this reason, A? has become a major target for the development of drugs designed to reduce its formation (Vassar et al., 1999), or to activate mechanisms that …
Sheep whole genome molecular probe combination, gene chip and its application
… of new animal and plant varieties and has achieved good results (Li Chenglan, Guo Tingting, Yue Yaojing. Research progress on genomic selection and its application in sheep breeding [J]. Chinese Journal of Animal Husbandry and Veterinary Medicine, 2023, 50(02): 616-625. DOI: 10.16431/j.cnki.1671- …
Incorporation of unnatural nucleotides and methods thereof
… is synthesized in a cell-free translation system. In some embodiments, the method is utilized for generation of probes, unnatural polypeptides, unnatural macrocycles, site-specific antibody-drug conjugate, bispecific antibodies, nucleic acid catalysts, biosensors, kill switch, and gene delivery.
T cell recruiting polypeptides capable of binding CD123 and TCR alpha/beta
Polypeptides are provided that bind CD123 on a target cell and the constant domain of TCR on a T cell. The polypeptides can be used in methods for treatment of CD123 associated cancers or inflammatory conditions.