… wherein the one or more additional agents is selected from the group consisting of aducanumab, solanezumab, CSP-1103, Mannitol, Osmitrol, Resectisol, Phenytoin, Dilantin, Phenytek, valproic acid, Depakote, Gabapentin, Neurontin, Topiramate, Topamax, Carbamazepine, Equetro, anti-platelet medications …
Category: Patent
Method of dietary treatment for genetic and epigenetic diseases and disorders
Abildgaard, C. et al. Bioenergetic modulation with dichloroacetate reduces the growth of melanoma cells and potentiates their response to BRAFV600E inhibition. Journal of Translational Medicine 12:247 (2014). Agnoletto, C. et al. Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic …
Modulators of thr-beta and methods of use thereof
[004] In the United States alone, MASH is the third most common indication for liver transplantation and is on a trajectory to become the most common [4], The most important medical need in patients with MASLD and MASH is an effective treatment to halt the progression and possibly reverse fibrosis, …
Wound healing medicament
, Journal of Materials Chemistry B. 2014). In vivo heparin binds and releases VEGF and other pro-angiogenic mitogens (Ferrara N et al., Nature medicine. 2003). VEGF activates the proliferation and migration of endothelial cells in both normal and tumour tissue and results in rapid generation of new …
Method for creating human large organ with which vascular anastomosis can be …
Characteristics of human pluripotent stem cell (hiPSC)-liver organoids (LO) loaded with hiPSC-large vessels (BV). (A) Electron microscopy images of hepatocytes (left), rough endoplasmic reticulum and mitochondria (center) within hepatocytes, and bile canaliculi formed between hepatocytes (right) …
Modulators of thr-beta and methods of use thereof
In the United States alone, NASH is the third most common indication for liver transplantation and is on a trajectory to become the most common [4]. The most important medical need in patients with NAFLD and NASH is an effective treatment to halt the progression and possibly reverse fibrosis, which …
Treatment of metastatic cancer and model systems for metastatic disease
The present invention is further based, in part, on the discovery that L1CAM inhibition inhibited the growth of chemoresistant lung cancer xenografts, supporting a mechanism of action distinct from cytotoxic drugs, and that inhibition of L1CAM was observed to render chemoresistant tumor cells …